Reaktion #90991

Reaktionsgleichung

Methyl 3,5-dichloro-4-(cyclopentyloxy)benzoate

lithium hydroxide

water

→

3,5-dichloro-4-(cyclopentyloxy)benzoic acid

Ausbeute 82.1%

3,5-Dichloro-4-(cyclopentyloxy)benzoic acid

Ausbeute 82.1%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeformed
2. 2
   SonstigeThe THF was removed in vacuo
3. 3
   FiltrationThe resultant precipitate was filtered

Vorschrift

Methyl 3,5-dichloro-4-(cyclopentyloxy)benzoate (2) (1.05 g, 3.63 mmol) and lithium hydroxide (174 mg, 7.26 mmol) were combined in THF (10 mL) and water (ca. 1.5 mL) was added dropwise until a solution formed. The resultant mixture was stirred at RT for 12 h. The THF was removed in vacuo and the residue acidified using aqueous HCl (1 M). The resultant precipitate was filtered to afford 3,5-dichloro-4-(cyclopentyloxy)benzoic acid (3) (820 mg, 82%): m/z 273 (M−H)− (ES−).

Quelle