Reaktion #90944

Reaktionsgleichung

tert-butyl (2-nitro-4-(thiophen-2-yl)phenyl)carbamate

→

tert-butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate

Ausbeute 69.4%

Lösungsmittel

ethanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction was filtered
2. 2
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

To a solution of tert-butyl (2-nitro-4-(thiophen-2-yl)phenyl)carbamate (2 g, 6.2 mmol, 1.0 eq.) in ethanol (20 mL) and methanol (20 mL) was added 10% Pd/C (0.66 g, 0.1 eq.). The reaction mixture was stirred 12 h under a hydrogen atmosphere. The reaction was filtered and the filtrate was concentrated under reduced pressure to give tert-butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate (1.25 g, 69% yield) as an off-white solid.

Quelle