Reaktion #90906

Reaktionsgleichung

Magnesium chloride

1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone

magnesium chloride

Triethylamine

magnesium chloride

triethylamine

triethylamine

Diethyl [(phenylsulfonyl)methyl]phosphonate

→

2-(3,5-dichlorophenyl)-3,3,3-trifluoroprop-1-en-1-yl phenyl sulfone

Ausbeute 98.0%

Lösungsmittel

acetonitrile

ethyl acetate

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONwas nearly dissolved
2. 2
   Sonstigewas obtained
3. 3
   workup.ADDITIONwere added
4. 4
   workup.STIRRINGthe mixture was stirred for additional 30 minutes
5. 5
   Sonstigethe phases were separated
6. 6
   ExtraktionAfter extracting the aqueous phase twice with ethyl acetate (100 mL) the combined organic phases
7. 7
   Waschenwere washed three times with water (100 mL), three times with saturated sodium bicarbonate solution (100 mL)
8. 8
   Trocknendried over sodium sulfate
9. 9
   Filtrationfiltered
10. 10
    Sonstigethe solvents evaporated
11. 11
    SonstigeThe yellow oil was recrystallized from n-heptane

Vorschrift

Magnesium chloride (dry, 3.16 g, 33.2 mmol) was put in a flask under a nitrogen atmosphere and acetonitrile (100 mL) was added. The mixture was stirred for five minutes at room temperature. Diethyl [(phenylsulfonyl)methyl]phosphonate (10.0 g, 89% purity, 30.4 mmol) was added. After 5 minutes stirring the magnesium chloride was nearly dissolved. Triethylamine (5.01 mL, 35.9 mmol) was added and after 10 minutes at room temperature a yellow solution was obtained. Then 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone (6.89 mg, 98% purity, 27.7 mmol) was added. After stirring for one hour additional magnesium chloride (0.1 eq.) and triethylamine (0.1 eq.) were added and the mixture was stirred for additional 30 minutes. Then, additional triethylamine (0.1 eq.) was added. Water (100 mL) and ethyl acetate (200 mL) were added and the phases were separated. After extracting the aqueous phase twice with ethyl acetate (100 mL) the combined organic phases were washed three times with water (100 mL), three times with saturated sodium bicarbonate solution (100 mL), dried over sodium sulfate, filtered and the solvents evaporated. The yellow oil was recrystallized from n-heptane. 2-(3,5-dichlorophenyl)-3,3,3-trifluoroprop-1-en-1-yl phenyl sulfone was obtained (10.5 g, 97% purity, 98% yield, E/Z (not assigned)=64/36).

Quelle