Reaktion #90887

ord-273eca5867b241388ceba11b41776f3b

Reaktionsgleichung

CC(=O)NC12CC(O)(C1)C2
N-(3-hydroxybicyclo[1.1.1]pentan-1-yl)acetamide
CC(=O)NC12CC(O)(C1)C2
N-(3-hydroxybicyclo[1.1.1]-pentan-1-yl)acetamide
CC(=O)Oc1ccccc1C(=O)Cl
O-acetylsalicyloyl chloride
→
CC(=O)NC12CC(OC(=O)c3ccccc3OC(C)=O)(C1)C2
3-acetamidobicyclo[1.1.1]pentan-1-yl 2-acetoxybenzoate

Edukte

CC(=O)NC12CC(O)(C1)C2
N-(3-hydroxybicyclo[1.1.1]pentan-1-yl)acetamide
CC(=O)NC12CC(O)(C1)C2
N-(3-hydroxybicyclo[1.1.1]-pentan-1-yl)acetamide
CC(=O)Oc1ccccc1C(=O)Cl
O-acetylsalicyloyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The general procedure of Example 1 Step 3 is repeated starting with N-(3-hydroxybicyclo[1.1.1]pentan-1-yl)acetamide (1) and using O-acetylsalicyloyl chloride in place of the acetyl chloride to produce 3-acetamidobicyclo[1.1.1]pentan-1-yl 2-acetoxybenzoate (8).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09447025B2uspto-grants-2016_09