Reaktion #90850

Reaktionsgleichung

D-serine

Acetyl chloride

→

D-serine methyl ester hydrochloride

Ausbeute 91.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 15 hours
2. 2
   SonstigeEvaporation of the reaction mixture under reduced pressure
3. 3
   Sonstigefollowed by crystallization of the resulting residue from methanol and methyl tert-butyl ether

Vorschrift

D-serine (100 g, 0.9515 mole) was suspended in 600 ml methanol at room temperature. Acetyl chloride (224.0 g, 2.8545 mole) was added drop wise at −5° C. to 0° C. and stirred for 30 minutes. The reaction mixture was refluxed for 15 hours. Evaporation of the reaction mixture under reduced pressure followed by crystallization of the resulting residue from methanol and methyl tert-butyl ether, resulted in colorless solid of D-serine methyl ester hydrochloride (134.7 g, Yield: 91%, HPLC: 99.6%)

Quelle