Reaktion #9064

Reaktionsgleichung

4-(Benzimidazol-2-yl)-benzyl alcohol

→

4-(benzimidazol-2-yl)-benzaldehyde

Ausbeute 42.0%

Lösungsmittel

CH2Cl2

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered through celite
2. 2
   Waschenthe cake washed with CH2Cl2
3. 3
   Sonstigethe solvent from the eluent removed under reduced pressure

Vorschrift

4-(Benzimidazol-2-yl)-benzyl alcohol from above (0.175 g, 0.78 mmol) was dissolved in CH2Cl2 (5 mL) and THF (8 mL), treated with activated MnO2 (0.68 g, 7.8 mmol) and stirred at room temperature for 1.5 h. The mixture was filtered through celite, the cake washed with CH2Cl2 and the solvent from the eluent removed under reduced pressure to afford 4-(benzimidazol-2-yl)-benzaldehyde (92 mg, 42%). 1H NMR (CD4OD) δ 7.28 (m, 2H), 7.60 (br, 1H (NH)), 7.65 (d, 2H, J=7.8 Hz), 8.09 (d, 2H, J=7.8 Hz), 8.30 (d, 2H, J=9.0 Hz), 10.08 (s, 1H (CHO)).

Quelle