Reaktion #90399

Reaktionsgleichung

VII

(E)-N′-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

6-aminobenzimidazole

KBr

→

9-(1H-Benzo[d]imidazol-6-ylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Ausbeute 98.0%

Lösungsmittel

DCM MeOH

Reaktionsbedingungen

Vorschrift

Prepared from VII and 6-aminobenzimidazole. Flash chromatography eluent (DCM-MeOH 8:2). Yield: 98%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 3084, 2226, 1615, 1557, 1464, 1376, 1347, 1248, 1147, 967, 939, 809; 1H NMR (300 MHz, DMSO-d6) δ 8.48 (d, 1H, J=8.7 Hz), 8.15-8.10 (m, 2H), 8.02 (m, 1H), 7.75 (d, 1H, J=8.7 Hz), 7.56 (m, 1H), 7.04 (m, 1H); HRMS calcd for C17H10N7S (M+H+): 344.0718, found 344.0705.

Quelle