Reaktion #90333

Reaktionsgleichung

acetonitrile

2-(4-(1-(4-(perfluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)acetyl azide

2-isopropylaniline

cesium carbonate

→

title compound

Ausbeute 22.0%

1-(2-isopropylphenyl)-3-(4-(1-(4-(perfluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzyl)urea

Ausbeute 22.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe suspension was cooled to room temperature
2. 2
   workup.STIRRINGto stir for overnight at room temperature
3. 3
   FiltrationThe reaction was filtered through a fritted funnel
4. 4
   EinengenThe filtrate was concentrated onto Celite®
5. 5
   Sonstigepurified by reverse phase chromatography

Vorschrift

To a 20 mL vial, 2-(4-(1-(4-(perfluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)acetyl azide (0.100 g, 0.228 mmol) was suspended in acetonitrile (1.5 mL). The suspension was stirred in a pre-heated heating block at 70° C. for 2 hours. The suspension was cooled to room temperature, then 2-isopropylaniline (0.0339 g, 0.251 mmol) and cesium carbonate (0.0890 g, 0.274 mmol) were added. The reaction was allowed to stir for overnight at room temperature. The reaction was filtered through a fritted funnel. The filtrate was concentrated onto Celite® and purified by reverse phase chromatography using 5-100% acetonitrile/water as eluent to provide the title compound as a white solid (0.028 g, 22%).

Quelle