Reaktion #9029

Reaktionsgleichung

2,2,2-trifluoro-1-piperazin-1-yl-ethanone

allyl bromide

potassium carbonate

→

piperazine

Ausbeute 155.1%

1-allyl-piperazine

Ausbeute 155.1%

Lösungsmittel

CH3CN

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with CH2Cl2 (30 mL) and water (30 mL)
3. 3
   Extraktionthe aqueous layer extracted with CH2Cl2 (2×20 mL)
4. 4
   TrocknenThe combined organic extracts were dried (Na2SO4)
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

To a stirred solution of 2,2,2-trifluoro-1-piperazin-1-yl-ethanone (515 mg, 2.83 mmol) in dry CH3CN (6 mL) was added allyl bromide (0.32 mL, 3.7 mmol) and powdered potassium carbonate (0.78 g, 5.65 mmol) and the mixture stirred overnight. The reaction was concentrated under reduced pressure, diluted with CH2Cl2 (30 mL) and water (30 mL) and the aqueous layer extracted with CH2Cl2 (2×20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo to afford the crude di-protected piperazine (0.554 g) which was used without further purification in the next reaction.

Quelle