Reaktion #90287

Reaktionsgleichung

2-chloro-5-(trifluoromethyl)pyridine

5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole

potassium carbonate

→

2-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-2H-tetrazol-2-yl)-5-(trifluoromethyl)pyridine

Lösungsmittel

acetonitrile

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   SonstigeThe organic phase was separated
3. 3
   Trocknendried over anhydrous magnesium sulphate
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated to dryness
6. 6
   Sonstigeto leave a crude residue that
7. 7
   Sonstigewas recrystallised from a dichloro-methane/isopropanol mixture

Vorschrift

2-chloro-5-(trifluoromethyl)pyridine (0.181 g, 1.00 mmol) was added to a stirred suspension of 5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole (0.4 g, 1.00 mmol) and potassium carbonate (0.14 g, 1 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature till completion, then diluted with dichloromethane and washed with water. The organic phase was separated, dried over anhydrous magnesium sulphate, filtered and evaporated to dryness to leave a crude residue that was recrystallised from a dichloro-methane/isopropanol mixture to afford 2-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-2H-tetrazol-2-yl)-5-(trifluoromethyl)pyridine, 0.389 g (71%).

Quelle