Reaktion #9028

Reaktionsgleichung

piperazine

trifluroacetic acid ethyl ester

→

piperazine

Ausbeute 58.0%

2.2,2-trifluoro-1-piperazin-1-yl-ethanone

Ausbeute 58.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was concentrated
2. 2
   Sonstigepurified by column chromatography on silica gel (CH2Cl2/MeOH, 9:1)

Vorschrift

To a solution of piperazine (1.444 g, 16.8 mmol) in MeOH (10 mL) was added trifluroacetic acid ethyl ester (2.0 mL, 16.8 mmol) and the mixture stirred at room temperature overnight. The reaction was concentrated and purified by column chromatography on silica gel (CH2Cl2/MeOH, 9:1) to afford the desired mono-protected piperazine adduct (1.77 g, 58%) as a pale yellow oil. 1H NMR (CDCl3) δ 1.70 (br s, 1H), 2.90–2.94 (m, 4H), 3.56–3.59 (m, 2H), 3.64–3.67 (m, 2H).

Quelle