Reaktion #90192

Reaktionsgleichung

2-(2-bromo-4-methoxyphenyl)-propan-2-ol

2,3-benzofuran

→

title compound

Ausbeute 51.0%

2-[1-(2-Bromo-4-methoxyphenyl)-1-methylethyl]benzofuran

Ausbeute 51.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM
2. 2
   SonstigeThe residues obtained
3. 3
   Einengenafter concentration under reduced pressure
4. 4
   Sonstigewere purified by silica gel column (DCM/hexane)

Vorschrift

Mixture comprising 2-(2-bromo-4-methoxyphenyl)-propan-2-ol (100 mg), 2,3-benzofuran (0.19 ml) and polyphosphoric acid (1 g) was stirred and heated at 90° C. for 30 min. The reaction mixture was added with water and extracted with DCM. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM/hexane) to obtain the title compound (143 mg, 51%).

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