Reaktion #90191

Reaktionsgleichung

1-(2-bromo-4-methoxyphenyl)-ethanone

MeMgBr

ammonium chloride

→

title compound

Ausbeute 69.0%

2-(2-Bromo-4-methoxy-phenyl)-propan-2-ol

Ausbeute 69.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed with saturated brine
3. 3
   Sonstigethe residues obtained
4. 4
   Einengenafter concentration under reduced pressure
5. 5
   Sonstigewere purified by silica gel column (ethyl acetate/hexane)

Vorschrift

To the mixture of 1-(2-bromo-4-methoxyphenyl)-ethanone (300 mg) dissolved in THF solution (3 ml), MeMgBr (3 M THF solution, 0.52 ml) was added at 0° C. under nitrogen atmosphere. Then, the mixture was stirred at room temperature for 6 hrs. The reaction mixture was added with saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (220 mg, 69%).

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