Reaktion #90145

Reaktionsgleichung

trifluoroacetic acid

7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

7-Methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

Compound A2

7-Methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

sodium t-butoxide

tri-t-butylphosphonium tetrafluoroborate

dipotassium hydrogen phosphate

→

title compound

Ausbeute 36.0%

3-(2,4-Dihydroxy-phenyl)-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

Ausbeute 36.0%

Lösungsmittel

methanol

toluene

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   workup.STIRRINGstirred at room temperature overnight
3. 3
   Waschenthe organic layer was washed with saturated brine
4. 4
   TrocknenThereafter, the organic layer was dried over magnesium sulfate
5. 5
   SonstigeThe residues obtained
6. 6
   Einengenafter concentration under reduced pressure
7. 7
   Sonstigewere purified by silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

To 7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound A2, 10 g), 2-bromo-1,3-dihydroxytetrahydropyranbenzene (Compound Z9, 20.98 g), sodium t-butoxide (5.88 g), palladium acetate (550 mg) and tri-t-butylphosphonium tetrafluoroborate (710 mg), toluene (40 mL) was added and the mixture was stirred and heated at 70° C. under nitrogen atmosphere for 6 hr. After cooling, the reaction mixture was added with methanol (38 mL) and trifluoroacetic acid (14.54 mL) at room temperature, and then stirred at room temperature overnight. To the resulting residues, methylene chloride and saturated dipotassium hydrogen phosphate were added and the organic layer was washed with saturated brine. Thereafter, the organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (5.53 g, 36%).

Quelle