Reaktion #89973

ord-213e1c182f19404991b4d7baba766601

Reaktionsgleichung

CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
Compound A6
CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
8-Hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
CC(C)(C)OC(=O)NCCO
(2-hydroxy-ethyl)-carbamic acid tert-butyl ester
→
CC(C)(C)OC(=O)NCCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O
title compound
CC(C)(C)OC(=O)NCCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O
[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-ethyl]-carbamic acid tert-butyl ester

Edukte

CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
Compound A6
CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
8-Hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
CC(C)(C)OC(=O)NCCO
(2-hydroxy-ethyl)-carbamic acid tert-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeUnder the same conditions as the method for synthesizing Compound A7-1

Vorschrift

Under the same conditions as the method for synthesizing Compound A7-1, the title compound was prepared from Compound A6 and (2-hydroxy-ethyl)-carbamic acid tert-butyl ester.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09440922B2uspto-grants-2016_09