Reaktion #89915

Reaktionsgleichung

2-amino-4,5-dimethoxybenzamide

3-nitro benzoyl chloride

→

4,5-dimethoxy-2-(3-nitrophenyl)aminobenzamide

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo and residue
2. 2
   Sonstigewas triturated with Et2O
3. 3
   Filtrationfiltered
4. 4
   Sonstigedried under high vacuum

Vorschrift

To a suspension of 2-amino-4,5-dimethoxybenzamide (5.05 g, 25.7 mmole) and 3-nitro benzoyl chloride (5.2 g, 28.0 mmole) CHCl3 (120 ml) was added pyridine (50 ml) drop wise at RT. The reaction mixture was stirred at RT for 24 h. The solvent was removed in vacuo and residue was triturated with Et2O, filtered and dried under high vacuum to give 4,5-dimethoxy-2-(3-nitrophenyl)aminobenzamide, which was used directly in the next step.

Quelle