Reaktion #89908

Reaktionsgleichung

2-amino-5-methoxybenzamide

pyridine

3-nitrobenzoyl chloride

→

5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide

Ausbeute 133.6%

Lösungsmittel

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles were removed in vacuo
2. 2
   Waschenthe resultant solid was washed with Et2O

Vorschrift

To a suspension of 2-amino-5-methoxybenzamide (2.42 g, 14.6 mmol) and pyridine (6 mL) in CHCl3 (120 mL) was added 3-nitrobenzoyl chloride (3.0 g, 16.1 mmol). The resulting mixture was stirred at RT for 6 h. The volatiles were removed in vacuo and the resultant solid was washed with Et2O to give the 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide (6.15 g) which was taken directly on to the next step. HPLC retention time 6.58 mins.

Quelle