Reaktion #89730

Reaktionsgleichung

Lithium hexamethyldisilazide

1-benzyl 4-methyl(2S)-2-[benzyl((2R)-2-(1-ethoxyethoxy)-3-[(4-methylphenyl)sulfonyl]oxypropyl)amino]succinate

toluene

→

product

Ausbeute 78.2%

2-benzyl 3-methyl(2S,3S,5S)-1-benzyl-5-(1-ethoxyethoxy)piperidine-2,3-dicarboxylate

Ausbeute 78.2%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm up to at 0 Celsius gradually
2. 2
   workup.STIRRINGstirred at 0 Celsius for 30 min
3. 3
   SonstigeAfter quenched with aq ammonium chloride
4. 4
   Extraktionthe mixture was extracted with ethyl acetate
5. 5
   WaschenThe combined organic layers were washed with water, brine
6. 6
   Trocknendried (sodium sulfate)
7. 7
   Einengenconcentrated
8. 8
   Sonstigeto dry
9. 9
   SonstigeThe residue was purified on silica gel column
10. 10
    Wascheneluting with 0 to 20% EtOAc in hexane

Vorschrift

To a solution of 1-benzyl 4-methyl(2S)-2-[benzyl((2R)-2-(1-ethoxyethoxy)-3-[(4-methylphenyl)sulfonyl]oxypropyl)amino]succinate (34.30 g, 0.05464 mol) in a mixture of tetrahydrofuran (90.0 mL, 1.11 mol) and toluene (470.0 mL, 4.412 mol) at −78 Celsius was added 1.00 M of Lithium hexamethyldisilazide in tetrahydrofuran (65.6 mL). The resulting mixture was stirred at −78 Celsius overnight, and then allowed to warm up to at 0 Celsius gradually and stirred at 0 Celsius for 30 min. After quenched with aq ammonium chloride, the mixture was extracted with ethyl acetate. The combined organic layers were washed with water, brine, and dried (sodium sulfate), and concentrated to dry. The residue was purified on silica gel column, eluting with 0 to 20% EtOAc in hexane, to yield the cyclized product (19.47 g, 78.2%). MS (ESI): (M+H)+=456.0.

Quelle