Reaktion #89602

Reaktionsgleichung

Isopropylmagnesium chloride

1-Isopropyl-2,4-dimethyl-cyclohex-3-enecarbaldehyde

→

(1-isopropyl-2,4-dimethyl-cyclohex-3-enyl)-methanol

Lösungsmittel

tetrahydrofuran

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas then fed for over 2 hours at 0° C. under nitrogen
2. 2
   Sonstigequenched
3. 3
   workup.ADDITIONby pouring the reaction mixture onto a sulfuric acid solution (10%)
4. 4
   Sonstigeon crushed ice
5. 5
   SonstigeThe organic layer was separated
6. 6
   Waschenwashed with sodium carbonate solution
7. 7
   workup.DISTILLATIONdistilled

Vorschrift

Isopropylmagnesium chloride ((CH3)2HCMgCl) in tetrahydrofuran (THF) (1.6 L, 3.2 mol) was loaded into a flame-dried 5 L round bottom flask. Additional THF (1 L) was added. 1-Isopropyl-2,4-dimethyl-cyclohex-3-enecarbaldehyde (obtained as detailed above) was then fed for over 2 hours at 0° C. under nitrogen. The reaction mixture was aged at 0° C. for another 3 hours and then quenched by pouring the reaction mixture onto a sulfuric acid solution (10%) on crushed ice. The organic layer was separated, washed with sodium carbonate solution, and distilled to provide (1-isopropyl-2,4-dimethyl-cyclohex-3-enyl)-methanol.

Quelle