Reaktion #89367

Reaktionsgleichung

6-Methyl-3-(1H-pyrazol-1-yl)picolinonitrile

NaOH

AcOH

→

title compound

Ausbeute 94.0%

6-Methyl-3-(1H-pyrazol-1-yl)picolinic acid

Ausbeute 94.0%

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux overnight
2. 2
   SonstigeThe solvent was removed in vacuo
3. 3
   Sonstigeto obtain the crude which
4. 4
   Sonstigewas purified by silica gel chromatography (0˜100% DCM/EtOAc)

Vorschrift

6-Methyl-3-(1H-pyrazol-1-yl)picolinonitrile (0.60 g, 3.26 mmol) and NaOH (1.37 g, 34.2 mmol) were dissolved in methanol (3 mL) and stirred at reflux overnight. The reaction was cooled to rt, diluted with more methanol (5 mL), and acidified with AcOH to pH 4-5. The solvent was removed in vacuo to obtain the crude which was purified by silica gel chromatography (0˜100% DCM/EtOAc) to yield the title compound as a clear oil (0.62 g, 94%). MS (ESI) 204 (M+H).

Quelle