Reaktion #8929

Reaktionsgleichung

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

piperdine

→

benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   Einengenthen concentrated in vacuo
3. 3
   WaschenThe organic phase was washed with brine
4. 4
   Sonstigedried
5. 5
   Einengenconcentrated in vacuo

Vorschrift

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1 g benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 25 mL CH2Cl2. The solution was cooled to 0° C. and 4 mL of piperdine was slowly added. The reaction was stirred 1 hour then concentrated in vacuo. The residue was partioned between ethyl acetate and water. The organic phase was washed with brine, dried, and concentrated in vacuo to give 1 g of benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate suitable for use without further purification.

Quelle