Reaktion #8927

Reaktionsgleichung

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

dimethylamine

→

benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 100 mL round bottomed flask equipped with magnetic stir bar
2. 2
   EinengenAfter 30 minutes the reaction was concentrated in vacuo
3. 3
   SonstigeThe organic phase was dried
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A 100 mL round bottomed flask equipped with magnetic stir bar was charged with 1.7 g benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 25 mL CH2Cl2. The solution was cooled to −78° C. and 15 mL of anhydrous dimethylamine was slowly added. After 30 minutes the reaction was concentrated in vacuo and the residue was partioned between EA/H2O. The organic phase was dried, concentrated in vacuo to yield 1.4 g of benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate as a clear amber oil which was used directly in the next step.

Quelle