Reaktion #8920

Reaktionsgleichung

product

1-({6-(2-Chlorophenyl)-5-(4-chlorophenyl)-3-[(1-methyl-1H-imidazol-2-yl)carbonyl]pyridin-2-yl}oxy)-3,3-dimethylbutan-2-one

1,8-diazabicyclo[5.4.0]undec-7-ene

→

title compound

1-[6-(2-Chlorophenyl)-5-(4-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)furo[2,3-b]pyridin-2-yl]-2,2-dimethylpropan-1-one

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas placed in a 10 mL reaction tube of a CEM Corporation Discover 300 Watt microwave reactor
2. 2
   SonstigeThe reaction vessel was sealed
3. 3
   TemperaturAfter the reaction vessel had cooled again to room temperature
4. 4
   Sonstigethe reaction mixture was partitioned between EtOAc and saturated aqueous NaHCO3 solution
5. 5
   SonstigeThe organic layer was separated
6. 6
   Waschenwashed with aq. NaHCO3, brine
7. 7
   Trocknendried (Na2SO4)
8. 8
   Filtrationfiltered
9. 9
   Sonstigeevaporated
10. 10
    SonstigeThe residue was purified on a silica gel flash chromatography column
11. 11
    Wascheneluted with 0–75% EtOAc-hexane
12. 12
    SonstigeEvaporation of the purified fractions
13. 13
    Sonstigedrying in vacuo

Vorschrift

A mixture of 0.094 g (0.18 mmol) of the product of Step B and 0.027 g (0.18 mmol) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in 2 mL DMF was placed in a 10 mL reaction tube of a CEM Corporation Discover 300 Watt microwave reactor. The reaction vessel was sealed, placed in the microwave reactor and heated at 150° C. for 5 min. After the reaction vessel had cooled again to room temperature, the reaction mixture was partitioned between EtOAc and saturated aqueous NaHCO3 solution. The organic layer was separated, washed with aq. NaHCO3, brine, dried (Na2SO4), filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 0–75% EtOAc-hexane. Evaporation of the purified fractions and drying in vacuo afforded the title compound. HPLC/MS: 504.2 (M+1), 506.0 (M+3); Rt=3.39 min.

Quelle