Reaktion #89148

ord-b6d9eefc6b694479bdfc197219fb860b

Reaktionsgleichung

C[C@H]1CCCN[C@H]1CNC(=O)OC(C)(C)C
rac-cis-tert-butyl ((3-methylpiperidin-2-yl)methyl)carbamate
[Na+].[OH-]
NaOH
C=CCOC(=O)Cl
allyl chloroformate
→
C=CCOC(=O)N1CCC[C@H](C)[C@@H]1CNC(=O)OC(C)(C)C
rac-cis-Allyl 2-(((tert-butoxycarbonyl)amino)methyl)-3-methylpiperidine-1-carboxylate

Edukte

C[C@H]1CCCN[C@H]1CNC(=O)OC(C)(C)C
rac-cis-tert-butyl ((3-methylpiperidin-2-yl)methyl)carbamate
[Na+].[OH-]
NaOH
C=CCOC(=O)Cl
allyl chloroformate

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

To the mixture of rac-cis-tert-butyl ((3-methylpiperidin-2-yl)methyl)carbamate (9.48 g, 41.53 mmol) in THF (25 mL) was added NaOH (2 M, 25 mL), followed by allyl chloroformate (6.65 mL, 62.3 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09440982B2uspto-grants-2016_09