Reaktion #8914

ord-c381bed665bb4627a586bfbdff44fdf8

Reaktionsgleichung

Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
product
Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
[3-Amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)furo[2,3-b]pyridin-2-yl](pyridin-3-yl)methanone
CC(=O)OCC(=O)Cl
acetoxyacetyl chloride
→
O=C(CO)Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
title compound
O=C(CO)Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
N-[6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(pyridin-3-ylcarbonyl)furo[2,3-b]pyridin-3-yl]-2-hydroxyacetamide

Edukte

Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
product
Nc1c(C(=O)c2cccnc2)oc2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)cc12
[3-Amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)furo[2,3-b]pyridin-2-yl](pyridin-3-yl)methanone
CC(=O)OCC(=O)Cl
acetoxyacetyl chloride
—
ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the general acylating procedure described in Example 18, the product of Example 157 was reacted with acetoxyacetyl chloride and then subjected to the general ester hydrolysis procedure described in Example 25 to afford the title compound. HPLC/MS: 518.0 (M+1), 520.0 (M+3); Rt=3.52 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091216B2uspto-grants-2006_08