Reaktion #8913

Reaktionsgleichung

product

1-[3-Amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)furo[2,3-b]pyridin-2-yl]-2-hydroxy-2-methylpropan-1-one

acetic anhydride

→

N-[6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(2-hydroxy-2-methylpropanoyl)furo[2,3-b]pyridin-3-yl]acetamide

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter 3 h the reaction was concentrated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
3. 3
   Waschenwashed twice with aqueous sodium bicarbonate
4. 4
   EinengenThe solution was then concentrated
5. 5
   Sonstigethe residue was purified via flash chromatography on silica gel with gradient elution of 0–60% ethyl acetate in hexanes affording the title compound

Vorschrift

The product of Example 100 (0.200 g), acetic anhydride (1.25 mL) and acetic acid (0.25 mL) were combined and then heated to 85° C. After 3 h the reaction was concentrated and the residue was dissolved in dichloromethane and washed twice with aqueous sodium bicarbonate. The solution was then concentrated and the residue was purified via flash chromatography on silica gel with gradient elution of 0–60% ethyl acetate in hexanes affording the title compound. HPLC/MS: 483.0 (M+1), 484.8 (M+3); Rt=3.95-min.

Quelle