Reaktion #88890

Reaktionsgleichung

ethyl 2-chloronicotinate

tributyl(1-ethoxyvinyl)tin

→

title compound

ethyl 2-(1-ethoxyvinyl)nicotinate

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated under reduced pressure
2. 2
   Sonstigethe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
3. 3
   Sonstigepurified by silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

To a mixture of ethyl 2-chloronicotinate (23 g), tributyl(1-ethoxyvinyl)tin (64 mL) and toluene (400 mL) was added tetrakis(triphenylphosphine)palladium(0) (7.3 g), and the mixture was stirred overnight at 80° C. under an argon atmosphere. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane), and then purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (27 g).

Quelle