Reaktion #88230

Reaktionsgleichung

dimethyl 3-oxopentanedioate

CH(OEt)3

urea

→

title compound

Ausbeute 82.3%

Dimethyl 4-oxo-1,4-dihydropyridine-3,5-dicarboxylate

Ausbeute 82.3%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 3 hours
3. 3
   Filtrationthe precipitate was filtered
4. 4
   Waschenwashed with xylene and DCM

Vorschrift

A mixture of dimethyl 3-oxopentanedioate (12 g, 69 mmol), CH(OEt)3 (15.1 g, 100 mmol) and urea (6 g, 100 mmol) in xylene (25 mL) was heated to reflux for 3 hours. The mixture was cooled to room temperature and the precipitate was filtered, washed with xylene and DCM to afford the title compound as white solid (yield 82.3%).

Quelle