Reaktion #88217

Reaktionsgleichung

2-fluoro-4-methylsulfonyl-aniline

KOAc

Br2

→

desired product

2-bromo-6-fluoro-4-methanesulfonyl-phenylamine

Lösungsmittel

AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to 0° C.
2. 2
   workup.STIRRINGThe mixture was stirred for 30 min at 0° C
3. 3
   EinengenThe mixture was concentrated
4. 4
   WaschenThe organic mixture was washed (sat. NaHCO3, sat. Na2S2O3)
5. 5
   Trocknendried (Na2SO4)
6. 6
   Einengenconcentrated

Vorschrift

A mixture of 2-fluoro-4-methylsulfonyl-aniline (22.76 mmol) and KOAc (22.7 mmol) in AcOH was stirred at room temperature. The mixture was cooled to 0° C. and Br2 (22.7 mmol) was added dropwise. The mixture was stirred for 30 min at 0° C. The mixture was concentrated and the residue was taken up in EtOAc. The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3), dried (Na2SO4) and concentrated to yield the desired product.

Quelle