Reaktion #8817

Reaktionsgleichung

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride

diisopropylethylamine

→

2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one

Ausbeute 29.9%

Lösungsmittel

2-methoxyethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo
2. 2
   Sonstigeto give an oil residue, which
3. 3
   SonstigeThe white precipitate that formed
4. 4
   Filtrationwas collected by filtration

Vorschrift

A mixture of 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 1 (wherein R is methyl and Z is —C(O)—, 296 mg, 1.24 mmol), 1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride 15a (440 mg, 1.54 mmol)) and diisopropylethylamine (1.2 g, 9.26 mmol) in 2-methoxyethanol (10 mL) was stirred at 120° C. for 6 hours. The reaction mixture was concentrated in vacuo to give an oil residue, which was diluted with water. The white precipitate that formed was collected by filtration to give 155 mg of 2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one 501, [M+H]+=418.

Quelle