Reaktion #88081

Reaktionsgleichung

4-amino-3-nitro-benzoic acid

chloride

methanol

→

4-amino-3-nitro-benzoic acid methyl ester

Ausbeute 81.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturto reflux overnight
3. 3
   Filtrationfiltered
4. 4
   FiltrationThe solid recovered by filtration
5. 5
   Waschenwas rinsed with cold methanol
6. 6
   Sonstigedried

Vorschrift

To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mmol) suspended in methanol (150 mL) was added thiony chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.

Quelle