Reaktion #8795

Reaktionsgleichung

4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine

phosphorus oxychloride

water

→

target compound

Ausbeute 97.0%

4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine

Ausbeute 97.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe precipitated crystal was separated
2. 2
   Waschenthe resultant crystal was washed
3. 3
   Sonstigedried

Vorschrift

13.8 kg of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine and 11.5 kg of phosphorus oxychloride were refluxed in acetonitrile, and stirred for 4 hours. The reaction solution was combined with water, and the precipitated crystal was separated, and the resultant crystal was washed and dried to obtain 14.6 kg of the target compound as a pale yellow crystal.

Quelle