Reaktion #87683

ord-f307a7d3412647da9c443a172da55893

Reaktionsgleichung

NC(=O)c1ccc(F)c(C(F)(F)F)c1
4-fluoro-3-(trifluoromethyl)benzamide
O=C(Cl)C(=O)Cl
oxalyl chloride
→
O=C=NC(=O)c1ccc(F)c(C(F)(F)F)c1
desired product
O=C=NC(=O)c1ccc(F)c(C(F)(F)F)c1
4-Fluoro-3-(trifluoromethyl)benzoyl isocyanate

Edukte

NC(=O)c1ccc(F)c(C(F)(F)F)c1
4-fluoro-3-(trifluoromethyl)benzamide
O=C(Cl)C(=O)Cl
oxalyl chloride

Reagenzien

Keine

Lösungsmittel

ClCCCl
EDC

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe title compound was prepared

Vorschrift

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-fluoro-3-(trifluoromethyl)benzamide (0.200 g), oxalyl chloride (0.012 mL) and EDC (15 mL) to afford 0.150 g of the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09439890B2uspto-grants-2016_09