Reaktion #87666

Reaktionsgleichung

N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide

NaNO2

SnCl2.2H2O

→

desired product

N-(4-chloro-2-fluoro-5-hydrazinylbenzyl)-2,2,2-trifluoroacetamide

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared

Vorschrift

The title compound was prepared according to the procedure described in step-1 of Intermediate-61 by using N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide (2.0 g, 0.007 mmol), NaNO2 (0.612 g, 0.008 mmol), SnCl2.2H2O (4.10 g, 0.018 mmol), and conc. HCl (100 mL) to afford 1.0 g of the desired product.

Quelle