Reaktion #87649

ord-42eae47f28024009a15b7de6a01799ba

Reaktionsgleichung

COc1cc(Cl)c(C(N)=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide
O=C(Cl)C(=O)Cl
oxalyl chloride
→
COc1cc(Cl)c(C(=O)N=C=O)cc1CNC(=O)C(F)(F)F
desired product
COc1cc(Cl)c(C(=O)N=C=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

Edukte

COc1cc(Cl)c(C(N)=O)cc1CNC(=O)C(F)(F)F
5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide
O=C(Cl)C(=O)Cl
oxalyl chloride

Reagenzien

Keine

Lösungsmittel

ClCCCl
EDC

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe title compound was prepared

Vorschrift

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09439890B2uspto-grants-2016_09