Reaktion #87602

Reaktionsgleichung

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 18 h
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   Sonstigecrude reaction mixture

Vorschrift

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Quelle