Reaktion #87503

Reaktionsgleichung

N-(4-bromophenyl)-2-chloro-6-fluorobenzenecarbohydrazonoyl chloride

ammonia

→

desired product

N′-(4-bromophenyl)-2-chloro-6-fluorobenzenecarbo hydrazonamide

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mass was quenched in water
2. 2
   Extraktionextracted with DCM
3. 3
   TrocknenThe organic layer was dried over anhydrous sodium sulphate
4. 4
   Einengenconcentrated

Vorschrift

To a cold solution of N-(4-bromophenyl)-2-chloro-6-fluorobenzenecarbohydrazonoyl chloride (0.070 g, 0.267 mmol) in dry THF was added aq. ammonia. The reaction mass was stirred at 0-5° C. for 2-3 h. The reaction mass was quenched in water, neutralized with dilute acetic acid and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 0.040 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 6.29 (br s, 2H), 6.80 (d, J=8.4 Hz, 2H), 7.24 (d, J=9.3 Hz, 2H), 7.28-7.50 (m, 3H), 8.33 (s, 1H).

Quelle