Reaktion #8742

ord-753b8f4b0e8840059f919aa58a8e8fe8

Reaktionsgleichung

BrCCCOc1cccc(-c2noc3ccsc23)c1
3-[3-(3-bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole
ClCCCOc1cccc(-c2noc3ccsc23)c1
3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole
NCc1ccc(Cl)cc1
4-chlorobenzylamine
O=C([O-])[O-].[K+].[K+]
potassium carbonate
Clc1ccc(CNCCCOc2cccc(-c3noc4ccsc34)c2)cc1
title compound
Clc1ccc(CNCCCOc2cccc(-c3noc4ccsc34)c2)cc1
(4-chloro-benzyl)-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-amine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 4-chlorobenzylamine and potassium carbonate essentially as described above in example 4. Purity by LC/MS (APCI)=100%, [M+H]+=399 m/e.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091199B1uspto-grants-2006_08