Reaktion #8741

Reaktionsgleichung

3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

(3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

4-fluorobenzylamine

potassium carbonate

→

title compound

Ausbeute 94.0%

(4-fluoro-benzyl)-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-amine

Ausbeute 94.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenCombine the appropriate fractions and concentrate

Vorschrift

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[(3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 4-fluorobenzylamine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.36 g, 94% Yield) as an oil. Purity by LC/MS (APCI)=100% area, [M+H]+=383 m/e.

Quelle