Reaktion #87295

Reaktionsgleichung

2-Benzylidene-3-bromoindan-1-one

2-benzylidene-3-bromoindan-1-one

Cycloheptylamine

→

5

Ausbeute 82.0%

2-Benzylidene-3-cycloheptylaminoindan-1-one

Ausbeute 82.0%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction mixture
2. 2
   SonstigeSolvent was removed in vacuum

Vorschrift

2-Benzylidene-3-bromoindan-1-one 2 (299 mg, 1 mmol) was dissolved in benzene (10 mL). Cycloheptylamine (255 μL, 2 mmol) was added and reaction mixture was stirred for 24 h. Solvent was removed in vacuum and 5 (271 mg, 82%) was isolated as yellow crystals by column chromatography (Hexanes/EtOAc 9:1) followed by crystallization from dichloromethane with pentane.

Quelle