Reaktion #869

Reaktionsgleichung

HCl dioxane

N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine

→

(R)-α-methoxymethylbenzylamine hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITION30 ml of ether were added to the residue
3. 3
   Einengenthis was further concentrated

Vorschrift

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

Quelle