Reaktion #86840

Reaktionsgleichung

6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

4-isopropylaniline

→

pale green solid

Ausbeute 5.0%

1-(4-isopropylphenyl)-2-oxopyrrolidine-3-carboxylic acid

Ausbeute 5.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas irradiated in a microwave oven for 3 minutes at 100° C
2. 2
   EinengenThe mixture was concentrated under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue was dissolved in a solution of sodium hydroxide 6N
4. 4
   Waschenwashed with dichloromethane
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   Sonstigedried
7. 7
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.500 g; 2.94 mmol) and 4-isopropylaniline (1.21 mL; 8.82 mmol) in ethanol (3 mL) was irradiated in a microwave oven for 3 minutes at 100° C. The mixture was concentrated under reduced pressure and the residue was dissolved in a solution of sodium hydroxide 6N, washed with dichloromethane, acidified with a solution of hydrochloric acid 6N to pH=2, extracted with ethyl acetate dried and concentrated under reduced pressure to yield 0.036 g (5%) of a pale green solid, which was used in the next step without further purification.

Quelle