Reaktion #8670

Reaktionsgleichung

tert-butyl 7-benzyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

→

tert-Butyl 9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis carried out at 100° C.
2. 2
   FiltrationThe catalyst is filtered off with suction
3. 3
   Einengenthe filtrate is concentrated, whereupon 3.80 g (94.5% of theory) of pure product
4. 4
   Sonstigecrystallize out

Vorschrift

5.60 g (17.6 mmol) of tert-butyl 7-benzyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate are dissolved in 100 ml of ethanol, 1.00 g of 10% palladium on activated carbon is added, and hydrogenation is carried out at 100° C. and 100 bar. The catalyst is filtered off with suction, and the filtrate is concentrated, whereupon 3.80 g (94.5% of theory) of pure product crystallize out.

Quelle