Reaktion #86664

Reaktionsgleichung

EtOAc

DIBAL

Ester

(9R,12S,15S)-15-(4-Fluoro-benzenesulfonylamino)-12-isopropyl-11,14-dioxo-2-oxa-7-thia-10,13-diaza-bicyclo[15.2.2]henicosa-1(20),17(21),18-triene-9-carboxylic acid methyl ester

→

4-Fluoro-N-((9R,12S,15S)-9-formyl-12-isopropyl-11,14-dioxo-2-oxa-7-thia-10,13-diaza-bicyclo[15.2.2]henicosa-1(20),17(21), 18-trien-15-yl)-benzenesulfonamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to rt overnight
2. 2
   SonstigeThe reaction mixture was partitioned between EtOAc and 1M hydrochloric acid
3. 3
   ExtraktionThe aqueous phase was extracted again with EtOAc
4. 4
   Trocknenthe combined organic extracts were dried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo
7. 7
   SonstigePurification
8. 8
   Wascheneluting with a gradient of 1/1 EtOAc/(50/70) petroleum ether to EtOAc
9. 9
   Sonstigeto yield a light brown solid, 9 mg, 20%

Vorschrift

Ester 57 (47 mg) was dissolved in DCM (6 mL) under an atmosphere of argon. The reaction was cooled to −78° C. To the resultant solution DIBAL (0.42 mL) was added dropwise. This was stirred for 2 h before being allowed to warm to rt overnight. The reaction mixture was partitioned between EtOAc and 1M hydrochloric acid. The aqueous phase was extracted again with EtOAc and the combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Purification was achieved using flash chromatography, eluting with a gradient of 1/1 EtOAc/(50/70) petroleum ether to EtOAc to yield a light brown solid, 9 mg, 20%. Rf=0.45 (1/1 EtOAc/(50/70) petroleum ether).

Quelle