Reaktion #86599

Reaktionsgleichung

benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

→

2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalysis is separated by filtration over silica gel, before the solvent
2. 2
   Sonstigeis removed in vacuo
3. 3
   SonstigeGreen solid is obtained
4. 4
   Sonstigeit is suitable for further processing without purification

Vorschrift

573 mg of benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate (ZED1020, 1.54 mmol) are dissolved under nitrogen atmosphere in 100 mL of ethanol. To this solution 50 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 1 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Green solid is obtained and it is suitable for further processing without purification.

Quelle