Reaktion #86597

Reaktionsgleichung

N-(2-ethylbutyl)-2-(3-nitro-2-oxopyridin-1(2H)-yl)acetamide

→

2-(3-amino-2-oxopyridin-1(2H)-yl)-N-(2-ethylbutyl)acetamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalysis is separated by filtration over silica gel, before the solvent
2. 2
   Sonstigeis removed in vacuo
3. 3
   SonstigeGreen-gray solid is obtained
4. 4
   Sonstigeit is suitable for further processing without purification

Vorschrift

100 mg (0.36 mmol) of N-(2-ethylbutyl)-2-(3-nitro-2-oxopyridin-1(2H)-yl)acetamide are suspended under nitrogen atmosphere in 7 mL of methanol. To this solution 10 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 2 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Green-gray solid is obtained and it is suitable for further processing without purification.

Quelle