Reaktion #86544

Reaktionsgleichung

1,3-thiazol-2-amine

methyl 4-bromo-3-oxopentanoate

→

7-(1-bromoethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   FiltrationThe mixture was filtered
3. 3
   Sonstigethe collected precipitate was air-dried
4. 4
   Sonstigeto give crude product which

Vorschrift

A mixture of polyphosphoric acid (73.8 g, 677 mmol), 1,3-thiazol-2-amine (12.3 g, 123 mmol), and methyl 4-bromo-3-oxopentanoate (34.8 g, 166 mmol) was stirred at 110° C. overnight. After cooling, an ice-cold 10% aq. NaOH solution was slowly added to adjust the pH to 7. The mixture was filtered, and the collected precipitate was air-dried to give crude product which was directly used in next step. LCMS calculated for C8H8BrN2OS (M+H)+: m/z=259.0. Found: 259.0.

Quelle