Reaktion #86502

Reaktionsgleichung

2-(1-bromopropyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

N-iodosuccinimide

→

desired product

Ausbeute 90.5%

2-(1-bromopropyl)-3-iodo-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Ausbeute 90.5%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removal of acetonitrile in vacuum
2. 2
   workup.DISSOLUTIONthe resulting solid was dissolved in methylene chloride
3. 3
   Waschenwashed with water, saturated Na2S2O3, saturated sodium bicarbonate, and brine
4. 4
   Trocknenand then the organic layers dried over sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

A mixture of 2-(1-bromopropyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (3.46 g, 12.3 mmol) and N-iodosuccinimide (4.15 g, 18.4 mmol) in acetonitrile (100 mL) was stirred at 80° C., under nitrogen, overnight. After removal of acetonitrile in vacuum, the resulting solid was dissolved in methylene chloride, washed with water, saturated Na2S2O3, saturated sodium bicarbonate, and brine; and then the organic layers dried over sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure to provide the desired product (4.53 g, 90.4%). LCMS calculated for C12H13BrIN2O (M+H)+: m/z=406.9. Found: 407.1.

Quelle