Reaktion #8650

ord-7699baaddd76414b851d402dc61a2e83

Reaktionsgleichung

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
→
CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1
Fentanyl

Edukte

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol

Reagenzien

Keine

Lösungsmittel

O
water
O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONby mixing thoroughly in the bowl of a vacuum mixer
  2. 2
    TemperaturThe mix was then heated to 40° C.±2° C.
  3. 3
    workup.DISSOLUTIONdissolution of the solids
  4. 4
    TemperaturWhen cooled
  5. 5
    workup.STIRRINGThe mix was then homogenized
  6. 6
    workup.DISSOLUTIONdissolution of the solids
  7. 7
    workup.ADDITIONthe bulk mix
  8. 8
    workup.STIRRINGhomogenized
  9. 9
    workup.DISSOLUTIONdissolution

Vorschrift

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07090866B2uspto-grants-2006_08