Reaktion #86458

Reaktionsgleichung

methyl 2-chloro-6-fluoro-3,5-dimethoxybenzoate

sodium hydroxide

→

title compound

Ausbeute 76.7%

2-chloro-6-fluoro-3,5-dimethoxybenzoic acid

Ausbeute 76.7%

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 24 h
2. 2
   SonstigeThe resulting reaction mixture
3. 3
   Einengenconcentrated under vacuum
4. 4
   Sonstigeto get a crude residue
5. 5
   Extraktionextracted with ether (3×30 mL)
6. 6
   FiltrationHCl and the precipitated solid was filtered
7. 7
   Waschenwashed with cold water
8. 8
   Sonstigedried in vacuo

Vorschrift

A suspension of methyl 2-chloro-6-fluoro-3,5-dimethoxybenzoate (2.7 g, 0.010 mol) and sodium hydroxide (1.088 g, 0.0272) in anhydrous ethanol (30 mL) was refluxed for 24 h. The resulting reaction mixture was cooled to room temperature and concentrated under vacuum to get a crude residue. The crude residue was dissolved in water and extracted with ether (3×30 mL). The aqueous layer was acidified with conc.HCl and the precipitated solid was filtered, washed with cold water and dried in vacuo to afford the title compound (1.8 g, yield: 71%) as a solid.

Quelle